Atypical neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD)
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Atypical neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD). / Uhre, Camilla Funch; Ritter, Melanie; Jepsen, Jens Richardt Møllegaard; Uhre, Valdemar Funch; Lønfeldt, Nicole Nadine; Müller, Anne Dorothee; Plessen, Kerstin Jessica; Vangkilde, Signe; Blair, Robert James; Pagsberg, Anne Katrine.
In: European Child & Adolescent Psychiatry, Vol. 33, No. 7, 2024, p. 2291-2300.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Atypical neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD)
AU - Uhre, Camilla Funch
AU - Ritter, Melanie
AU - Jepsen, Jens Richardt Møllegaard
AU - Uhre, Valdemar Funch
AU - Lønfeldt, Nicole Nadine
AU - Müller, Anne Dorothee
AU - Plessen, Kerstin Jessica
AU - Vangkilde, Signe
AU - Blair, Robert James
AU - Pagsberg, Anne Katrine
N1 - © 2023. The Author(s).
PY - 2024
Y1 - 2024
N2 - Atypical neurocognitive functioning has been found in adult patients with obsessive-compulsive disorder (OCD). However, little work has been done in children and adolescents with OCD. In this study, we investigated neurocognitive functioning in a large and representative sample of newly diagnosed children and adolescents with OCD compared to non-psychiatric controls. Children and adolescents with OCD (n = 119) and non-psychiatric controls (n = 90) underwent psychopathological assessment, intelligence testing, and a neurocognitive test battery spanning cognitive flexibility, planning and decision-making, working memory, fluency, and processing speed. The MANOVA main effect revealed that children and adolescents with OCD performed significantly worse than the control group (p < .001, [Formula: see text] = 0.256). Atypical patient performance was particularly found for indices of cognitive flexibility, decision-making, working memory, and processing speed. We found no evidence of differences in planning or fluency. Moreover, we found no significant associations between neurocognitive performance and OCD symptom severity or comorbidity status. Our results indicate that children and adolescents with OCD show selective atypical neurocognitive functioning. These difficulties do not appear to drive their OCD symptoms. However, they may contribute to lifespan difficulties and interfere with treatment efficacy, an objective of our research currently.
AB - Atypical neurocognitive functioning has been found in adult patients with obsessive-compulsive disorder (OCD). However, little work has been done in children and adolescents with OCD. In this study, we investigated neurocognitive functioning in a large and representative sample of newly diagnosed children and adolescents with OCD compared to non-psychiatric controls. Children and adolescents with OCD (n = 119) and non-psychiatric controls (n = 90) underwent psychopathological assessment, intelligence testing, and a neurocognitive test battery spanning cognitive flexibility, planning and decision-making, working memory, fluency, and processing speed. The MANOVA main effect revealed that children and adolescents with OCD performed significantly worse than the control group (p < .001, [Formula: see text] = 0.256). Atypical patient performance was particularly found for indices of cognitive flexibility, decision-making, working memory, and processing speed. We found no evidence of differences in planning or fluency. Moreover, we found no significant associations between neurocognitive performance and OCD symptom severity or comorbidity status. Our results indicate that children and adolescents with OCD show selective atypical neurocognitive functioning. These difficulties do not appear to drive their OCD symptoms. However, they may contribute to lifespan difficulties and interfere with treatment efficacy, an objective of our research currently.
U2 - 10.1007/s00787-023-02301-w
DO - 10.1007/s00787-023-02301-w
M3 - Journal article
C2 - 37917157
VL - 33
SP - 2291
EP - 2300
JO - European Child and Adolescent Psychiatry, Supplement
JF - European Child and Adolescent Psychiatry, Supplement
SN - 1433-5719
IS - 7
ER -
ID: 387472810