The developmental trajectory of fronto-temporoparietal connectivity as a proxy of the default mode network: a longitudinal fNIRS investigation
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The developmental trajectory of fronto-temporoparietal connectivity as a proxy of the default mode network : a longitudinal fNIRS investigation. / Bulgarelli, Chiara; de Klerk, Carina C. J. M.; Richards, John E.; Southgate, Victoria; Hamilton, Antonia; Blasi, Anna.
In: Human Brain Mapping, Vol. 41, No. 10, 07.2020, p. 2717-2740.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The developmental trajectory of fronto-temporoparietal connectivity as a proxy of the default mode network
T2 - a longitudinal fNIRS investigation
AU - Bulgarelli, Chiara
AU - de Klerk, Carina C. J. M.
AU - Richards, John E.
AU - Southgate, Victoria
AU - Hamilton, Antonia
AU - Blasi, Anna
PY - 2020/7
Y1 - 2020/7
N2 - The default mode network (DMN) is a network of brain regions that is activated while we are not engaged in any particular task. While there is a large volume of research documenting functional connectivity within the DMN in adults, knowledge of the development of this network is still limited. There is some evidence for a gradual increase in the functional connections within the DMN during the first 2 years of life, in contrast to other functional resting-state networks that support primary sensorimotor functions, which are online from very early in life. Previous studies that investigated the development of the DMN acquired data from sleeping infants using fMRI. However, sleep stages are known to affect functional connectivity. In the current longitudinal study, fNIRS was used to measure spontaneous fluctuations in connectivity within fronto-temporoparietal areas-as a proxy for the DMN-in awake participants every 6 months from 11 months till 36 months. This study validates a method for recording resting-state data from awake infants, and presents a data analysis pipeline for the investigation of functional connections with infant fNIRS data, which will be beneficial for researchers in this field. A gradual development of fronto-temporoparietal connectivity was found, supporting the idea that the DMN develops over the first years of life. Functional connectivity reached its maximum peak at about 24 months, which is consistent with previous findings showing that, by 2 years of age, DMN connectivity is similar to that observed in adults.
AB - The default mode network (DMN) is a network of brain regions that is activated while we are not engaged in any particular task. While there is a large volume of research documenting functional connectivity within the DMN in adults, knowledge of the development of this network is still limited. There is some evidence for a gradual increase in the functional connections within the DMN during the first 2 years of life, in contrast to other functional resting-state networks that support primary sensorimotor functions, which are online from very early in life. Previous studies that investigated the development of the DMN acquired data from sleeping infants using fMRI. However, sleep stages are known to affect functional connectivity. In the current longitudinal study, fNIRS was used to measure spontaneous fluctuations in connectivity within fronto-temporoparietal areas-as a proxy for the DMN-in awake participants every 6 months from 11 months till 36 months. This study validates a method for recording resting-state data from awake infants, and presents a data analysis pipeline for the investigation of functional connections with infant fNIRS data, which will be beneficial for researchers in this field. A gradual development of fronto-temporoparietal connectivity was found, supporting the idea that the DMN develops over the first years of life. Functional connectivity reached its maximum peak at about 24 months, which is consistent with previous findings showing that, by 2 years of age, DMN connectivity is similar to that observed in adults.
KW - default mode network
KW - developmental trajectory
KW - fNIRS
KW - fronto-temporoparietal connectivity
KW - functional connectivity
KW - infants
KW - resting-state
KW - BRAIN FUNCTIONAL CONNECTIVITY
KW - RESTING-STATE NETWORKS
KW - FALSE DISCOVERY RATE
KW - CORPUS-CALLOSUM
KW - INFANT BRAIN
KW - HUMAN CORTEX
KW - SELF
KW - FMRI
KW - ARCHITECTURE
KW - REVEALS
U2 - 10.1002/hbm.24974
DO - 10.1002/hbm.24974
M3 - Journal article
C2 - 32128946
VL - 41
SP - 2717
EP - 2740
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 10
ER -
ID: 255046130