Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders. / Macoveanu, Julian; Mariegaard, Johanna; Petersen, Jeff Zarp; Fisher, Patrick M.; Vinberg, Maj; Jørgensen, Martin Balslev; Knudsen, Gitte Moos; Kessing, Lars Vedel; Miskowiak, Kamilla Woznica.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 125, 110767, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Macoveanu, J, Mariegaard, J, Petersen, JZ, Fisher, PM, Vinberg, M, Jørgensen, MB, Knudsen, GM, Kessing, LV & Miskowiak, KW 2023, 'Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 125, 110767. https://doi.org/10.1016/j.pnpbp.2023.110767

APA

Macoveanu, J., Mariegaard, J., Petersen, J. Z., Fisher, P. M., Vinberg, M., Jørgensen, M. B., Knudsen, G. M., Kessing, L. V., & Miskowiak, K. W. (2023). Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 125, [110767]. https://doi.org/10.1016/j.pnpbp.2023.110767

Vancouver

Macoveanu J, Mariegaard J, Petersen JZ, Fisher PM, Vinberg M, Jørgensen MB et al. Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2023;125. 110767. https://doi.org/10.1016/j.pnpbp.2023.110767

Author

Macoveanu, Julian ; Mariegaard, Johanna ; Petersen, Jeff Zarp ; Fisher, Patrick M. ; Vinberg, Maj ; Jørgensen, Martin Balslev ; Knudsen, Gitte Moos ; Kessing, Lars Vedel ; Miskowiak, Kamilla Woznica. / Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2023 ; Vol. 125.

Bibtex

@article{ee6a5f17b8b74c00aeb65ca0909181be,
title = "Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders",
abstract = "Bipolar disorder (BD) and major depressive disorder (MDD) are associated with cognitive and functional impairment. Cognitive impairment is often associated with dorsal prefrontal cortex (dPFC) hypo-activity, but the neuronal correlates of functional disability is largely unknown. In this study, 91 patients with affective disorders in full or partial remission (BD, n = 67; MDD, n = 24) with objectively verified cognitive impairment and substantial functional disability underwent neuropsychological assessment and functional magnetic resonance imaging (fMRI) scan during which they completed a strategic picture-encoding task. For comparison, 36 matched healthy controls underwent an identical test protocol. Patients showed encoding-related hypo-activity in the dPFC compared to controls. In patients, lower right dlPFC activity was associated with poorer overall functioning and more antipsychotic drug use. In conclusion, memory impairments were underpinned by failure to recruit the dPFC during task performance which was associated with impaired functioning in fully or partially remitted patients with affective disorders. This aberrant neurocircuitry activity has implications for the design of future pro-cognitive interventions that aim to improve not only cognition but also real-world functioning.",
keywords = "Affective disorders, Cognitive impairment, fMRI, Functional impairment",
author = "Julian Macoveanu and Johanna Mariegaard and Petersen, {Jeff Zarp} and Fisher, {Patrick M.} and Maj Vinberg and J{\o}rgensen, {Martin Balslev} and Knudsen, {Gitte Moos} and Kessing, {Lars Vedel} and Miskowiak, {Kamilla Woznica}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.pnpbp.2023.110767",
language = "English",
volume = "125",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders

AU - Macoveanu, Julian

AU - Mariegaard, Johanna

AU - Petersen, Jeff Zarp

AU - Fisher, Patrick M.

AU - Vinberg, Maj

AU - Jørgensen, Martin Balslev

AU - Knudsen, Gitte Moos

AU - Kessing, Lars Vedel

AU - Miskowiak, Kamilla Woznica

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Bipolar disorder (BD) and major depressive disorder (MDD) are associated with cognitive and functional impairment. Cognitive impairment is often associated with dorsal prefrontal cortex (dPFC) hypo-activity, but the neuronal correlates of functional disability is largely unknown. In this study, 91 patients with affective disorders in full or partial remission (BD, n = 67; MDD, n = 24) with objectively verified cognitive impairment and substantial functional disability underwent neuropsychological assessment and functional magnetic resonance imaging (fMRI) scan during which they completed a strategic picture-encoding task. For comparison, 36 matched healthy controls underwent an identical test protocol. Patients showed encoding-related hypo-activity in the dPFC compared to controls. In patients, lower right dlPFC activity was associated with poorer overall functioning and more antipsychotic drug use. In conclusion, memory impairments were underpinned by failure to recruit the dPFC during task performance which was associated with impaired functioning in fully or partially remitted patients with affective disorders. This aberrant neurocircuitry activity has implications for the design of future pro-cognitive interventions that aim to improve not only cognition but also real-world functioning.

AB - Bipolar disorder (BD) and major depressive disorder (MDD) are associated with cognitive and functional impairment. Cognitive impairment is often associated with dorsal prefrontal cortex (dPFC) hypo-activity, but the neuronal correlates of functional disability is largely unknown. In this study, 91 patients with affective disorders in full or partial remission (BD, n = 67; MDD, n = 24) with objectively verified cognitive impairment and substantial functional disability underwent neuropsychological assessment and functional magnetic resonance imaging (fMRI) scan during which they completed a strategic picture-encoding task. For comparison, 36 matched healthy controls underwent an identical test protocol. Patients showed encoding-related hypo-activity in the dPFC compared to controls. In patients, lower right dlPFC activity was associated with poorer overall functioning and more antipsychotic drug use. In conclusion, memory impairments were underpinned by failure to recruit the dPFC during task performance which was associated with impaired functioning in fully or partially remitted patients with affective disorders. This aberrant neurocircuitry activity has implications for the design of future pro-cognitive interventions that aim to improve not only cognition but also real-world functioning.

KW - Affective disorders

KW - Cognitive impairment

KW - fMRI

KW - Functional impairment

U2 - 10.1016/j.pnpbp.2023.110767

DO - 10.1016/j.pnpbp.2023.110767

M3 - Journal article

C2 - 37068543

AN - SCOPUS:85152655265

VL - 125

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

SN - 0278-5846

M1 - 110767

ER -

ID: 363359561